IVF Failure – Why and What Next

In vitro fertilization (IVF) has been a ray of hope for couples having difficulty conceiving naturally. You can get help from fertility specialists with decades of experience, like some of the best gynecologist in Mumbai at Budget Fertility Center.

Dr. Hrishikesh Pai Created on 28th Jan, 23

In vitro fertilization (IVF) has been a ray of hope for couples having difficulty conceiving naturally. However, despite its high success rates, IVF does not always guarantee a successful pregnancy.


This can be devastating for couples pinning their hope on it to conceive and become parents. They feel lost and depressed.

Do not lose hope. IVF failure does mean that you cannot realize your dream of parenthood. It often takes two or more IVF cycles to be successful.


No doubt, fertility treatments can take a toll on you emotionally, physically, and financially.But remember, you can get help from fertility specialists with decades of experience, like some of the best gynecologist in Mumbai at Budget Fertility Center.


If your IVF cycle fails, our highly qualified IVF doctor in Mumbai will discuss the cause of the failure and use the information to increase your chances of success the next time you try the procedure.

Given below are some of the common causes of your IVF failure.

Woman’s age

A woman's age plays a significant role in the success of the IVF cycle. As they grow older, the quality and quantity of eggs decrease, affecting the likelihood of pregnancy or live birth following IVF.

Women under the age of 35 have the highest probability of IVF success, says Dr. Hrishikesh Pai, the co-founder of Budget Fertility Center, a well-known IVF center in Mumbai.

Ovarian response

At the start of the IVF cycle, the woman must take hormone injections every day to boost egg production. This medicine can cause some women's ovaries to react improperly, which prevents them from producing enough eggs for retrieval. This mostly happens to older women who have a low ovarian reserve.

However, the poor ovarian response does not imply that you cannot undergo IVF. Investigations and medication adjustments might be able to improve the issue.

Your doctor will conduct a blood test and ultrasound to check the ovarian reserve. Accordingly, they will decide the appropriate treatment plan and hormone dosage to trigger your ovaries to produce enough oocytes.

Issues with implantation

It indicates that the embryos did not successfully attach to the uterus. It could happen due to many factors, such as thin endometrial lining, scar tissue, uterine polyps, high levels of progesterone, or a uterine infection. 

Dr. Hrishikesh Pai, one of the best gynecologist in Mumbai, explains, "Most of the time, implantation complications are beyond anyone's control. We perform a series of teststo look for potential reasons for implantation failure so that we can address the issue for a better outcome in the next cycle.”

Chromosomal abnormalities

The embryo's chromosomal abnormality is another factor that frequently prevents them from implanting. Chromosomal anomalies may be inherited from one of the parents or may arise during the initial stages of embryonic development.

Chromosome-deficient eggs are more common in women over 35, and the risk increases with age.

Preimplantation genetic testing (PGT) helps ascertainthe embryo's genetic health and is crucial to the success of IVF. The fertility specialist will only use healthy embryos for the transfer, thereby increasing the chances of implantation.


Everyone wants to be an ideal IVF candidate, which could entail following a nutritious diet and leading a healthy lifestyle.

Smoking will adversely affect the success of your IVF. Smoking increases the risk of miscarriage and often doubles the number of IVF cycles needed to conceive. You are more likely to have a failed IVF procedure if you are underweight or overweight.


What next after a failed IVF?

It is natural to feel sad and depressed after a failed IVF cycle. But remember, it is not the end of the road. 

Consult your fertility doctor to learn the causes of the failure before trying again. It might help you and your doctor understand the problems and whether they can be addressed. 

You must be mentally and emotionally ready to repeat the IVF cycle. While undergoing IVF, stress management is a crucial factor to consider because couples may continue to feel nervous and tense in anticipation of the results. 

Before starting the next IVF cycle, the doctor may perform a few tests to find out the root cause of IVF failure, such as:

  • Sperm assessment
  • Infection screening
  • Immune testing
  • Karyotyping
  • Checking the uterine cavity

Donor eggs might be an option for women with few or nonviable eggs. Furthermore, you can choose from alternatives like adoption and surrogacy if your body is not ready for additional cycles or if there is an underlying condition.



Avoid searching for pregnancy hacks or worrying about your fertility issues, as it will not solve your problem but can raise your anxiety levels. Instead, visit a reputed fertility center with a high success rate for your IVF treatment. 


At Budget Fertility Center, we have treated many couples who were unsuccessful in their fertility treatment. We are one of the leading clinics for IVF treatment in Mumbai


Our IVF doctors are experts in handling challenging cases with advanced treatments and cutting-edge equipment and technologies, giving prospective parents new hope.